|ICAN / INSERM||Director||fr|
Karine Clément, MD, PhD is full professor of Nutrition at University Pierre and Marie Curie, Pitié-Salpêtrière Hospital in Paris. She is the former director (2011-2017) of the Institute of Cardio-metabolism and Nutrition (ICAN, www.ican-institute.org) and of an INSERM/university team called “NutriOmics”. Her team works on several aspects of the complex pathophysiology of human obesity, particularly exploring tissue alterations (such as adipose tissue depots, liver, intestine), modified cross-talks and links with comorbidities during human obesity progression and weight loss. Clinical models include dietary and bariatric surgery induced weight loss and improved metabolism in which large scale “omics” approach are conducted. Her team showed notably the importance of low-grade inflammation and fibrotic processes in human adipose depots and the links with local and systemic metabolic alterations. More recently, K Cléments’ team investigated gut microbiota changes induced by dietary changes and bariatric surgery and described significant modifications of bacterial gene richness, bacterial groups and links with metabolic and inflammation phenotypes related to obesity. She published > 300 publications in the field. She is a member and expert of several national and international scientific committees in obesity and metabolism and contributes to several European Networks in genetics and functional genomics (Diogenes, Hepadip, ADAPT, FLIP, ePos). She now coordinates METACARDIS, a European program on gut microbiota and cardiometabolic and nutrition-related diseases (http://www.metacardis.net).
-Clement K, Vaisse C, et al . A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998 26;392(6674):398-401.
-Kühnen P, Clément K, et al. Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist. N Engl J Med. 2016 Jul 21;375(3):240-6.
-Marcelin G, Ferreira A, Liu Y, Atlan M, Aron-Wisnewsky J, Pelloux V, Botbol Y, Ambrosini M, Fradet M, Rouault C, Hénégar C, Hulot JS, Poitou C, Torcivia A, Nail-Barthelemy R, Bichet JC, Gautier EL, Clément K. A PDGFRα-Mediated Switch toward CD9(high) Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis. Cell Metab. 2017 Mar 7;25(3):673-685
-Monteiro-Sepulveda M, Touch S, Mendes-Sá C, André S, Poitou C, Allatif O, Cotillard A, Fohrer-Ting H, Hubert EL, Remark R, Genser L, Tordjman J, Garbin K, Osinski C, Sautès-Fridman C, Leturque A, Clément K*, Brot-Laroche E*. Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling. Cell Metab. 2015 Jul 7;22(1):113-24.
-Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger EO, Kayser BD, Levenez F, Chilloux J, Hoyles L; MICRO-Obes Consortium, Dumas ME, Rizkalla SW, Doré J, Cani PD, Clément K. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016 Mar;65(3):426-36.
– Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E, Almeida M, Quinquis B, Levenez F, Galleron N, Gougis S, Rizkalla S, Batto JM, Renault P; ANR MicroObes consortium, Doré J, Zucker JD, Clément K, Ehrlich SD. Dietary intervention impact on gut microbial gene richness. Nature. 2013 Aug 29;500(7464):585-8.